Choline compound having laxative properties



Patented 9, 1924.

'UNITED STATES PATENT OFFlCE.--.

J'URGEN CALLSEN, OF ELBERFELD, GERMANY, ASSIGNOR TO FARBENFABRIKEN VOBM. FRIEDB. BAYER AND ('10., OF LEVERKUSEN, NEAR COLOGNE-ON-THE-RHINE,

GERMANY.

' CHOLINE COMPOUND HAVING LAXATIVE PROPERTIES.

No Drawing.

or its derivatives in which the hydrogen atom of the hydroxyethyl group is replaced by a hydroxyalkyl radicle, such as The new compounds possess valuable pharmaceutical properties similar to those of the alkaloid arecolin. They are laxatives which-can be used for subcutaneous injections.

Their salts, for example the bromides, iodides and nitrates, possess the valuable properties of the bases and are whitish crystalline materials, soluble in water and alcohol, an average subcutaneous dose being about 0.05 gram. I

Application filled February 14, 1924. 'Serial No. 692,883.

In order to illustrate my new invention more fully, the following example is given, the parts being by weight To 133 parts of 'dimethylaminoethylglycol Y 400 parts by weight of a per cent solution of methylbromide in benzene is added taking care to cool. A syrup is obtained which solidifies to a crystalline mass, which is recrystallized from alcohol.

The resulting hydroxyethylethertrimethylammoniumbromide is a whitish crystalline powder easily soluble in water and in alcohol, insoluble in ben-' I OH:

HO- CHr-UHr-O-CHz-CHr-N(CH3);

being a white crystalline powder, ea" uble in water and alcohol, insoluble i' loom zene and ether, melting at 8386 C. and be ing a valuable laxative for subcutaneous use, substantially as described.

In testimony whereof I' hav'e hereunto'fset my hand. I

JUBGEN CALLSEN. 

